Linux version

There is a third-party port of the game linthesia, but it is quite old and doesn't include all the nice new features in the learning pack.

Synthesia can be run in wine, setup wine as per your distro, Ubuntu (and mint) can use the wine ppa.

Wine 1.2 is reported to work, more tweaks are needed before it runs with 1.3, but try and let us know if you work it out.

You need to install a daemon (software synthetizer), you have two options

Timidity

See this forum post for Timidity as a daemon

LinuxSampler

See this forum post for LinuxSampler. LinuxSampler is probably the better method but involves compiling code.

Windowed mode

Change the window options with winecfg.

Applications -> Add application (select Synthesia.exe and select new entry "Synthesia.exe")
Graphics -> De-Select "Allow the window manager to decorate the windows" (if selected)
Graphics -> Select "Emulate a virtual desktop" and enter your screen resolution

The sound on the right hand is missing when a note played with the left starts at the same time, the

missing note is when you are watching both hands, if you watch left and play right it works, so minor overall

the top button 'video settings' crashes, so use winecfg, the 'advanced settings' button works fine